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Most people who are chronically ill (more than 1 in 2 according to the Centers for Disease Control as reported in 2000), the causes are most often related to a initial infection.The latest PCR (polymerase chain reaction) DNA test research at U.C. Irvine and University of Pennsylvania suggests most infectious agents induce chronic disease syndromes. Therefore identifying these patterns will positively affect health and allow opportunities to reduce the impact of chronic disease by preventing and treating infection. As a consequence, we list the fourth step to great health for most Americans as the prevention and elimination of chronic disease by identifying the root causes related to the initial stimulus of the infection and ultimately restoring physiologic balance.